5,7-dichloro-7aH-imidazo[4,5-b]pyridine

5,7-dichloro-7aH-imidazo[4,5-b]pyridine - Names and Identifiers

Name	5,7-dichloro-7aH-imidazo[4,5-b]pyridine
Synonyms	Nsc264046 7-dichloro-1H-iMidazo[4 5,7-Dichloroimidazo[4,5-b]pyridine 5,7-Dichloro-3H-imidazo[4,5-b]pyridine 5,7-Dichloro-1H-imidazo[4,5-b]pyridine 5,7-dichloro-1H-imidazo[4,5-b]pyridine 5,7-dichloro-7aH-imidazo[4,5-b]pyridine 1H-IMidazo[4,5-b]pyridine, 5,7-dichloro- 1H-imidazo[4,5-b]pyridine, 5,7-dichloro- 3H-Imidazo[4,5-b]pyridine, 5,7-dichloro- (1)5,7-dichloro-3H-imidazo[4,5-b]pyridine
CAS	24485-01-6
InChI	InChI=1/C6H3Cl2N3/c7-3-1-4(8)11-6-5(3)9-2-10-6/h1-2,5H

5,7-dichloro-7aH-imidazo[4,5-b]pyridine - Physico-chemical Properties

Molecular Formula	C6H3Cl2N3
Molar Mass	188.01
Density	1.79±0.1 g/cm3(Predicted)
Melting Point	273-274 °C
Boling Point	200.8±50.0 °C(Predicted)
Flash Point	119.4°C
Vapor Presure	0.00936mmHg at 25°C
pKa	5.37±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.768

5,7-dichloro-7aH-imidazo[4,5-b]pyridine - Introduction

5,7-dichloro-7ah-imidazo [4,5-b]pyridine is an organic compound with the chemical formula C8H4Cl2N2. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White or light yellow crystal powder
-Melting Point: about 176-179 ℃
-Boiling point: About 358-359 ℃
-Solubility: Slightly soluble in ethanol, insoluble in water

Use:
-As an intermediate in organic synthesis, it is widely used in the synthesis of other organic compounds and drugs.
-Can be used to synthesize biologically active compounds, such as anti-tumor agents.

Method:
5,7-dichloro-7ah-imidazo [4,5-b]pyridine can be prepared in many ways. The following is one of the common methods:
1.5-chloropyridine and O-nitrobenzene naphthalene are reacted in a mixed acid of sulfuric acid and nitric acid to generate 7-nitro -5-chloropyridine.
2. The 7-nitro-5-chloropyridine is reacted with sulfuric acid and sodium nitrite in an ice bath to obtain 5,7-dichloropyridine.
3. Finally, 5,7-dichloropyridine and urea are cyclized in dimethyl sulfoxide to generate 5,7-dichloro-7ah-imidazo [4,5-b]pyridine.

Safety Information:
-5,7-dichloro-7ah-imidazo [4,5-b]pyridine is an organic compound with certain toxicity and irritation.
-Wear appropriate protective equipment such as lab gloves, goggles and protective clothing when used.
-Avoid contact with skin, eyes and respiratory tract.
-Ensure good ventilation during operation.
-Avoid contact with strong oxidants during storage.
-Before use and handling, carefully read and follow the relevant safety instructions and operating procedures.

Last Update：2024-04-09 21:00:56